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Jul 7, 2023

What does the body of evidence say on the topic of bioidentical hormones? Plus: a new gene therapy troublingly gets approved by the FDA, and Health Canada finally changes how it regulates natural health products (a little).

Block 1:

(2:19) Bioidentical hormones: sex hormones, hormone replacement therapy, testosterone replacement therapy, and what “bioidentical hormone” means

Block 2:

(9:36) Bioidentical hormones: biosimilars, compounding pharmacies, regulation, the all-natural claim, why bioidentical hormones are not safer, and the individualization claim

Block 3:

(22:17) A controversial new gene therapy for Duchenne muscular dystrophy

Block 4:

(39:32) Health Canada is coming for your vitamins (or not)


* Jingle by Joseph Hackl

* Theme music: “Fall of the Ocean Queen“ by Joseph Hackl

* Assistant researcher: Aigul Zaripova

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1) Our previous episode on menopause and hormone replacement therapy:

2) Our previous episode on testosterone:

3) Chris’ article on the overprescription of testosterone therapy:

4) Jonathan’s article on biosimilars:

5) A recent New England Journal of Medicine study about testosterone safety:

6) FDA review of compounded products:

7) Report of endometrial cancer in women using compounded hormonal therapy:

8) Jonathan’s article on Duchenne muscular dystrophy gene therapy:

9) Health Canada’s changes to the regulation of natural health products:


It’s Not Twitter, But It’ll Do:

1) Jonathan’s article on the milkmaid myth:

2) Jonathan quoted in TIME magazine about Andrew Huberman:

3) Pre-order Chris’ book!