May 7, 2024
What does the body of evidence say on lupus, the autoimmune disease that famously imitates so many other illnesses? Plus: a new study shows that Tylenol in pregnancy is not associated with neurodevelopmental problems, and Chris revisits the topic of red meat following a listener’s question.
A Block: Lupus
(0:57) How common lupus is; what may be causing it; what lupus looks like; how complicated its diagnosis is; what treatment options exist
B Block: Tylenol in Pregnancy
(34:27) Is Tylenol use in pregnancy really responsible for autism, ADHD, and intellectual disability? A new study says no.
C Block: Red Meat
(50:13) Are the harms of eating red meat regularly nowhere near as bad as we were told?
* Theme music: “Fall of the Ocean Queen“ by Joseph Hackl
* Assistant researcher: Aigul Zaripova
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References:
Lupus epidemiology:
1) https://www.lupuscanada.org/living-with-lupus/what-is-lupus/
2) https://doi.org/10.1177/096120339500400303
3) https://doi.org/10.1038/s41584-021-00668-1
Causes of lupus:
4) DOI: 10.1002/art.22510
5) DOI: 10.7326/0003-4819-142-12_part_1-200506210-00004
6) https://doi.org/10.1097/bor.0b013e32833c6297
7) https://doi.org/10.1016/0190-9622(90)70020-i
8) https://doi.org/10.1136/ard.2007.084582
9) DOI: 10.1177/0961203306069346
What lupus looks like in a patient:
10) https://dermnetnz.org/topics/cutaneous-lupus-erythematosus
11) https://dermnetnz.org/topics/discoid-lupus-erythematosus
12) doi: 10.2147/CCID.S269288
13) https://dermnetnz.org/topics/raynaud-phenomenon
14) DOI: 10.1097/01.md.0000091181.93122.55
15) DOI: 10.1002/art.39070
How to manage lupus:
16) DOI: 10.1136/annrheumdis-2015-207726
17) https://pubmed.ncbi.nlm.nih.gov/12784392/
18) DOI: 10.1016/j.jaad.2014.12.025
19) https://doi.org/10.1016/j.autrev.2017.02.005
20) DOI: 10.1191/096120398678919778
21) https://doi.org/10.1136/ard.2008.101766
22) DOI: 10.1056/NEJMoa035471
23) https://doi.org/10.1191/0961203305lu2039oa
24) DOI: 10.1002/14651858.CD010668.pub2
25) DOI: 10.1002/art.27233
26) DOI: 10.1002/art.34359
27) DOI: 10.1136/lupus-2018-000284
28) DOI: 10.1056/NEJMoa1912196
29) https://ash.confex.com/ash/2023/webprogram/Paper180547.html
30) https://doi.org/10.1016/C2009-0-02062-5
31) Study on Tylenol in pregnancy: https://doi.org/10.1001/jama.2024.3172